abstract：:The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...

journal_title：Biomarkers in medicine

authors： Banovic MD

更新日期：2017-04-01 00:00:00

abstract：AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...

journal_title：Biomarkers in medicine

authors： Tang X,Gao Y,Yu L,Lu Y,Zhou G,Cheng L,Sun K,Zhu B,Xu M,Liu J

更新日期：2017-03-01 00:00:00

abstract：AIM:This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHOD:We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical L...

journal_title：Biomarkers in medicine

authors： Min GT,Wang YH,Yao N,Zhao JM,Wang J,Wang HP,Chen W,Deng SJ,Li YM

更新日期：2017-01-01 00:00:00

abstract：:The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-r...

journal_title：Biomarkers in medicine

authors： Lim JS,Sundar R,Chénard-Poirier M,Lopez J,Yap TA

更新日期：2017-01-01 00:00:00

abstract：AIM:To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa). MATERIALS & METHODS:CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downreg...

journal_title：Biomarkers in medicine

authors： Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

更新日期：2016-12-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the association of circulating miRNAs with white-coat hypertension (WCH) and further analyze whether miRNAs could be as potential biomarkers for WCH. METHOD:Quantitative reverse transcriptase PCR (qRT-PCR) was used to evaluate the expression of selected miRNAs. The a...

journal_title：Biomarkers in medicine

authors： Huang YQ,Huang C,Chen JY,Li J,Feng YQ

更新日期：2016-12-01 00:00:00

abstract：AIM:Sepsis is a critical condition that leads to high mortality and is the most common cause of death in intensive care units. Despite exhaustive efforts by the scientific community, a reliable biomarker for diagnosis, evolution and prognosis of sepsis is still lacking. Results & methodology: Here, using high-throughpu...

journal_title：Biomarkers in medicine

authors： Pinheiro da Silva F,Cataldi TR,de Lima TM,Starzynski PN,Barbeiro HV,Labate MT,CéMachado MC,de Souza HP,Labate CA

更新日期：2016-12-01 00:00:00

abstract：:Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colo...

journal_title：Biomarkers in medicine

authors： Gil J,Pesz KA,Sąsiadek MM

更新日期：2016-10-01 00:00:00

abstract：AIM:To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). PATIENTS & METHODS:Hundred RA and 100 controls were included. RESULTS:MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 an...

journal_title：Biomarkers in medicine

authors： Tecer D,Sezgin M,Kanık A,İncel NA,Çimen ÖB,Biçer A,Şahin G

更新日期：2016-09-01 00:00:00

abstract：AIM:To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission. MATERIALS & METHODS:Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without infl...

journal_title：Biomarkers in medicine

authors： Simm M,Söderberg E,Larsson A,Castegren M,Nilsen T,Eriksson M,Lipcsey M

更新日期：2016-08-01 00:00:00

abstract：:Major depressive disorder (MDD: unipolar depression) is widely distributed in the USA and world-wide populations and it is one of the leading causes of disability in both adolescents and adults. Traditional diagnostic approaches for MDD are based on patient interviews, which provide a subjective assessment of clinical...

journal_title：Biomarkers in medicine

authors： Bilello JA

更新日期：2016-08-01 00:00:00

abstract：AIM:To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS:Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model w...

journal_title：Biomarkers in medicine

authors： Jin YZ,Pei CZ,Wen LY

更新日期：2016-07-01 00:00:00

abstract：:In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, transcriptomic, proteomic, metabol...

journal_title：Biomarkers in medicine

authors： Liu ZP

更新日期：2016-06-01 00:00:00

abstract：AIM:The association between Lipoprotein (a) (Lp [a]) and common carotid intima media thickness (IMT) has been evaluated in 222 menopausal women. MATERIAL & METHODS:Lp (a) and IMT were measured, carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. RESULTS:Lp (a) was significan...

journal_title：Biomarkers in medicine

authors： Gentile M,Iannuzzo G,Mattiello A,Marotta G,Iannuzzi A,Panico S,Rubba P

更新日期：2016-01-01 00:00:00

abstract：:Generally, obese and overweight individuals display higher free fatty acid levels, which stimulate insulin resistance. The combination of overweight or obesity with insulin resistance can trigger Type 2 diabetes mellitus (T2DM) and are primary contributing factors to the development of uncontrolled T2DM. Genetic polym...

journal_title：Biomarkers in medicine

authors： Kasim NB,Huri HZ,Vethakkan SR,Ibrahim L,Abdullah BM

更新日期：2016-01-01 00:00:00

abstract：AIM:We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. PATIENTS & METHODS:In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were cla...

journal_title：Biomarkers in medicine

authors： Akboga MK,Balci KG,Maden O,Ertem AG,Kirbas O,Yayla C,Acar B,Aras D,Kisacik H,Aydogdu S

更新日期：2016-01-01 00:00:00

abstract：AIM:Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). METHODS:We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. R...

journal_title：Biomarkers in medicine

authors： Hung HC,Lu FH,Ou HY,Wu HT,Wu JS,Yang YC,Chang CJ

更新日期：2015-01-01 00:00:00

abstract：:Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...

journal_title：Biomarkers in medicine

authors： Caiazza F,Elliott L,Fennelly D,Sheahan K,Doherty GA,Ryan EJ

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors. METHO...

journal_title：Biomarkers in medicine

authors： Zhao X,Chen YX,Li CS

更新日期：2015-01-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is the fifth leading cause of cancer deaths in women. Developing adjuvant therapy to circumvent drug resistance represents an important aspect of current initiatives to improve survival in women with advanced EOC. A regulatory molecule that ...

journal_title：Biomarkers in medicine

authors： Nagaraj AB,Joseph P,DiFeo A

更新日期：2015-01-01 00:00:00

abstract：AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...

journal_title：Biomarkers in medicine

authors： Du T,Yang L,Luo H,Zhou P,Mei H,Xuan J,Xing Q,Ning B,Mendrick DL,Shi L

更新日期：2015-01-01 00:00:00

abstract：AIM:We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood. PATIENTS & METHODS:One-hundred-and-sixty-three patients with stable chronic heart failure followed at the card...

journal_title：Biomarkers in medicine

authors： Monfort A,Da Silva K,Vodovar N,Gayat E,Cohen-Solal A,Manivet P

更新日期：2015-01-01 00:00:00

abstract：:Dr Jake Micallef speaks to Hannah L Wilson, Commissioning Editor: Dr Micallef has 20 years of experience in research and development and in the management of early-stage biotechnical companies, including the manufacture of biotechnology products and the establishment of manufacturing operations. Dr Micallef gained thi...

journal_title：Biomarkers in medicine

authors： Micallef J,Wilson HL

更新日期：2014-01-01 00:00:00

abstract：AIM:Specific miRNA profiles have been identified for several samples from patients with bladder cancer. The results are not always congruent and partly contradictory. A comparison of published data was performed to select potential markers. MATERIALS & METHODS:A literature search in PubMed identified 79 articles publi...

journal_title：Biomarkers in medicine

authors： Tölle A,Ratert N,Jung K

更新日期：2014-01-01 00:00:00

abstract：AIM:The purpose of this study was to establish the influence of centrifugation and protease activity on the cerebrospinal fluid (CSF) concentrations of DJ-1 and hemoglobin. MATERIALS & METHODS:The concentrations of DJ-1 and hemoglobin were determined in 12 (DJ-1) and six (hemoglobin) pairs of CSF samples, with one sam...

journal_title：Biomarkers in medicine

authors： Salvesen L,Tanassi JT,Bech S,Pålhagen S,Svenningsson P,Heegaard NH,Winge K

更新日期：2014-01-01 00:00:00

abstract：:Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...

journal_title：Biomarkers in medicine

authors： Balling L,Gustafsson F

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis is a public health concern worldwide. Particularly worrying is the emergence of severe forms of drug resistance, such as extensively drug resistant and totally drug resistant tuberculosis, with few treatment options for the afflicted patients. To avoid further spread of drug resistance, its early detectio...

journal_title：Biomarkers in medicine

authors： Palomino JC,Vandamme P,Martin A

更新日期：2014-01-01 00:00:00

abstract：AIM:This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. METHODS:Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe obstruction; group 2 included ...

journal_title：Biomarkers in medicine

authors： Mohammadjafari H,Rafiei A,Kosaryan M,Yeganeh Y,Hosseinimehr SJ

更新日期：2014-01-01 00:00:00

abstract：:Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...

journal_title：Biomarkers in medicine

authors： Griffin M,Shennan AH

更新日期：2014-01-01 00:00:00

abstract：AIM:The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON). PATIENTS & METHODS:A total of 108 ON patients and urine samples were collected. An ELISA was used to determ...

journal_title：Biomarkers in medicine

authors： Xie Y,Xu W,Wang Q,Shao X,Ni Z,Mou S

更新日期：2014-01-01 00:00:00

abstract：AIM:The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD). METHODS:A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary...

journal_title：Biomarkers in medicine

authors： Harutyunyan M,Johansen JS,Mygind ND,Reuter SB,Kastrup J

更新日期：2014-01-01 00:00:00

abstract：:In order to individually tailor prostate cancer (PCa) treatment, clinicians need better tools to predict prognosis and treatment response. Given the relationship between angiogenesis and cancer progression, circulating endothelial cells (CECs) and their progenitors have logically been proposed as potential biomarkers....

journal_title：Biomarkers in medicine

authors： Reeves F,Sapre N,Corcoran N,Hovens C

更新日期：2013-12-01 00:00:00

abstract：AIM:Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. MATERIALS & METHODS:Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured a...

journal_title：Biomarkers in medicine

authors： Dedeoglu B,de Geus HR,Fortrie G,Betjes MG

更新日期：2013-12-01 00:00:00

abstract：:Bladder cancer is one of the most prevalent cancers worldwide. Early detection of bladder tumors is critical for improved patient outcomes. The standard method for detection and surveillance of bladder tumors is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have brought to light the ...

journal_title：Biomarkers in medicine

authors： Rosser CJ,Urquidi V,Goodison S

更新日期：2013-10-01 00:00:00

abstract：:The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...

journal_title：Biomarkers in medicine

authors： Rea G,Stewart FJ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. MATERIALS & METHODS:Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m(2)) and in 306 over- and normal-we...

journal_title：Biomarkers in medicine

authors： Vassalle C,Vigna L,Bianchi S,Maffei S,Novembrino C,De Giuseppe R,de Liso F,Vannucci A,Tirelli S,Maiavacca R,Bamonti F

更新日期：2013-08-01 00:00:00

abstract：:The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 an...

journal_title：Biomarkers in medicine

authors： Taubert H,Magdolen V,Kotzsch M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after b...

journal_title：Biomarkers in medicine

authors： Mizejewski GJ,Lindau-Shepard B,Pass KA

更新日期：2013-04-01 00:00:00

abstract：AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...

journal_title：Biomarkers in medicine

authors： Rahimi Z,Rahimi Z,Shahsavandi MO,Bidoki K,Rezaei M

更新日期：2013-02-01 00:00:00

abstract：:The prevalence of metabolic disorders (MDs), especially diabetes, is rapidly increasing worldwide, leading to an increasing risk of cardiovascular and other socially relevant complications. To boost MD biomarker discovery, advanced proteomics can harmonize metabolomics. Indeed, the rapid development of mass spectromet...

journal_title：Biomarkers in medicine

authors： Di Girolamo F,Del Chierico F,Caenaro G,Lante I,Muraca M,Putignani L

更新日期：2012-12-01 00:00:00